通过C-C激活策略从 (R) - 碳中合成 (-) - 希沙科林B
Isabel Kerschgens1, Alexander R Rovira1, Richmond Sarpong1
1Department of Chemistry , University of California-Berkeley , Berkeley , California 94720 , United States.
Journal of the American Chemical Society
|July 24, 2018
概括
这项研究展示了一种通过激活非反应性碳-碳键合成复杂分子结构的新方法. 该过程产生了独特的双循环框架,并用于二烯合成.
科学领域:
- 有机化学
- 合成化学
- 催化剂
背景情况:
- 传统上没有反应的碳-碳 (C-C) 键带来了合成的挑战.
- 开发新的C-C键激活方法对于复杂分子合成至关重要.
研究的目的:
- 为了展示一种利用C-C键激活的新合成途径.
- 通过carvone合成不寻常的bicyclo[3.3.1]和[3.2.1]框架.
- 将该序列应用于二二乙烯的合成.
主要方法:
- ((0)) 催化C-C键的激活.
- 激进的循环化过程.
- 自然产品的多步合成.
主要成果:
- 卡成功转化为双循环[3.3.1]和[3.2.1]骨架.
- 开发一个10步合成序列.
- 有效的二乙烯合成.
结论:
- 开发的方法为构建复杂的分子支架提供了一种新方法.
- 这是一个强大的合成策略.
- 这种方法可以合成具有挑战性的天然产品,
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