刺激和抑制的差异调整在子视觉皮层中的方向选择性
Daniel E Wilson1,2,3,4, Benjamin Scholl1, David Fitzpatrick5
1Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.
Nature
|July 27, 2018
概括
通过抑制对非偏好的运动的反应,皮层内抑制显著提高了子V1的方向选择性. 这是通过激发和抑制的差异调整实现的,特别是GABAergic神经元.
科学领域:
- 神经科学
- 视觉皮层研究
- 细胞电生理学
背景情况:
- 皮层神经元需要选择性反应来编码感官输入.
- 响应选择性受到突触输入,树突非线性和尖端值的影响.
研究的目的:
- 剖析导致子V1层2/3神经元的方向选择性反应的因素.
- 调查皮质内抑制在方向选择性的作用.
主要方法:
- 在体内记录整个细胞
- 双光子成像 (突触和细胞分辨率)
- GABA (γ-氨基黄油酸) 神经元选择性光遗传学
主要成果:
- 仅激发性输入并不能完全解释方向选择性.
- 低于值的反应显示方向选择性与尖端选择性相关.
- 激发和抑制的差异调整抑制了无方向反应.
- GABAergic神经元的光遗传性失活性降低了方向选择性.
- 抑制性神经元向偏好相反方向的刺激性神经元投射.
结论:
- 皮层内抑制是子V1方向选择性的重要决定因素.
- 抑制抑制对零运动方向的反应,从而增强选择性.
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