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Updated: Feb 7, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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新的线粒体DNA合成能够激活NLRP3炎症体

Zhenyu Zhong1,2, Shuang Liang3,4, Elsa Sanchez-Lopez1,2

  • 1Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA, USA.

Nature
|July 27, 2018
PubMed
概括

在慢性炎症疾病中,由CMPK2调节的线粒体DNA (mtDNA) 合成对NLRP3炎症酶激活至关重要. 这一发现为控制炎症提供了新的治疗点.

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