线粒体未折叠蛋白质响应是通过复原体依赖的Wnt信号进行细胞非自主介导的
Qian Zhang1, Xueying Wu2, Peng Chen1
1State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China; University of Chinese Academy of Sciences, 100049 Beijing, China.
Cell
|July 31, 2018
概括
线粒体的压力信号通过Wnt信号从神经元传递到其他组织. 这种细胞非自主性线粒体展开蛋白反应 (UPR) 涉及逆转激素复合体并保护生物体.
科学领域:
- 细胞生物学
- 神经科学
- 遗传学
背景情况:
- 线粒体功能障碍触发了线粒体展开的蛋白质反应 (UPR).
- 这种反应可以发生在非自主细胞中,表明压力信号的细胞间通信.
- 了解这些通讯途径对于生物保护至关重要.
研究的目的:
- 研究线粒体应激信号从神经系统传播到外围组织的机制.
- 确定参与细胞间通信的分子参与者.
主要方法:
- 使用C. elegans作为模型生物.
- 研究了在UPRmt中依赖于逆转子的Wnt信号的作用.
- 研究了神经元线粒体应激 (多Q40,cco-1减少) 对外围UPR的影响.
- 评估了逆转基因复合突变 (影响MIG-14) 和Wnt配体 (EGL-20) 的影响.
主要成果:
- 神经元线粒体应激会诱导Wnt依赖的,细胞非自主性的UPRmt.
- 对于Wnt分泌 (通过MIG-14) 至关重要的逆转基因复合物,是传播UPRmt信号所必需的.
- Wnt配体EGL-20的神经表达足以触发细胞非自主性UPR.
- 这种信号通路依赖于逆转激素复合体功能,Wnt信号和血清素.
结论:
- 从神经系统传递到外围组织的线粒体压力信号的关键媒介是Wnt信号传递.
- 逆转基因复合体在Wnt配体的分泌中起着至关重要的作用,促进了细胞间的通信.
- Wnt信号被确定为"线粒激素"信号的强有力的候选者,突出其在系统线粒体健康中的作用.
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