使用pH响应铁氧化物纳米组件对小肝细胞癌的高度敏感诊断
Jingxiong Lu, Jihong Sun1, Fangyuan Li
1Department of Radiology, Sir Run Run Shaw Hospital , Zhejiang University , Hangzhou 310016 , China.
Journal of the American Chemical Society
|July 31, 2018
概括
新的氧化铁纳米集群 (RIA) 可以更好地检测早期肝癌. 在酸性瘤环境中,这些pH反应剂从T2转化为T1对比剂,增强肝细胞癌 (HCC) 的可视化.
科学领域:
- 生物医学工程
- 纳米技术
- 医学成像
背景情况:
- 基于氧化铁纳米粒子 (IONP) 的对比剂对于使用磁共振成像 (MRI) 诊断肝脏病变至关重要.
- 目前的IONP药物在正常肝脏组织中显示单相对比增强,限制早期小肝细胞癌 (HCC) 的敏感性.
研究的目的:
- 开发新的pH响应铁氧化物纳米集 (RIAs) 以加强正常肝脏和HCC组织之间的区别.
- 创建一个具有反向对比增强效果的智能MRI对比剂,以改善HCC检测.
主要方法:
- 设计和合成i-motifDNA辅助的pH响应的氧化铁纳米集 (RIA).
- 研究由酸性瘤微环境引发的RIA分解.
- 在拆卸时放松率 (r2/r1) 变化的评估,将RIA从T2转换为T1对比剂.
- 在使用T1成像的正向HCC小鼠模型中验证反向对比增强效应.
主要成果:
- 在酸性瘤微环境中,RIA显示了pH响应性分解.
- 拆卸导致r2/r1比率显著下降,使RIA从T2转变为T1对比剂.
- 在体内T1成像模式下观察到正常肝脏变黑和HCC变亮的反向对比增强.
结论:
- 开发的RIA为下一代智能MRI对比剂提供了一种新的策略.
- 这种反向对比增强机制显著改善了正常肝脏和HCC组织之间的区别.
- 对RIA的pH反应性对HCC的早期和准确诊断具有前景.
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