脊椎动物神经和头骨的共同进化起源
Ryoko Horie1, Alex Hazbun1,2, Kai Chen1
1Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Nature
|August 3, 2018
概括
原脊椎动物Ciona intestinalis的侧板外皮表现出与脊椎动物相似的分隔. 这表明这个古老的系统中有个共同的进化起源.
科学领域:
- 发育生物学
- 进化生物学
- 遗传学
背景情况:
- 斑点和神经是脊椎动物的关键特征,但它们的进化关系尚不清楚.
- 侧板外皮在脊椎动物进化中的作用需要进一步研究.
研究的目的:
- 研究原脊椎动物Ciona intestinalis侧板外皮的特性.
- 探索神经的进化起源.
主要方法:
- 血统追踪
- 基因破坏试验
- 单细胞RNA测序 (scRNA-seq)
主要成果:
- 齐奥纳的侧板外皮与脊椎动物的神经板外皮具有类似的图案.
- 一个涉及Six1/2,Pax3/7和Msxb的调节网络控制细胞命运.
- 基因干扰将双极尾神经元 (神经状) 转化为触摸感觉细胞 (类似于斑块状).
结论:
- 侧板外皮分离早于脊椎动物.
- 这种系统很可能是头骨和神经的共同来源.
- 这些发现为脊椎动物细胞类型的深层进化历史提供了洞察力.
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