急性骨髓性白血病
Nicholas J Short1, Michael E Rytting2, Jorge E Cortes1
1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lancet (London, England)
|August 7, 2018
概括
最近的进展为急性髓性白血病 (AML) 提供了新的治疗方法,并改善了风险评估. 然而,患者的治疗结果仍然很差,因此需要对新疗法和组合进行临床试验,以进一步提高生存率.
科学领域:
- 血液学
- 癌症学
- 基因组学
背景情况:
- 几十年来,急性髓性白血病 (AML) 的治疗进展有限.
- 近年 (2017年以来) 在AML药物批准和生物理解方面取得了重大进展.
- 尽管有进展,但AML患者的治疗结果仍然不满意,死亡率很高.
研究的目的:
- 总结最近急性骨髓性白血病的治疗和生物学进展.
- 强调需要在AML治疗中继续进行研究和临床试验.
主要方法:
- 审查最近对AML药物的监管批准.
- 对AML生物学和基因组架构不断发展的理解分析.
- 检查包含分子偏差的最新风险分层指南.
主要成果:
- 自2017年以来,多种新药已被批准用于AML治疗.
- 现在精确的风险评估策略包括分子偏差来进行个性化管理.
- 超过一半的AML患者仍然死于这种疾病,
结论:
- 治疗急性髓性白血病的领域随着新疗法和诊断工具的迅速发展.
- 更好地了解AML基因组学有助于制定风险调整策略.
- 参与临床试验对于开发新组合和改善AML患者的存活率至关重要.
更多相关视频
06:33Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
Published on: November 10, 2023
1.9K
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
30.6K
相关概念视频
Differentiation of Common Myeloid Progenitor Cells
4.0K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.0K
Acute Pharyngitis
4.3K
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
4.3K
Acute Pancreatitis I: Introduction
1.3K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.3K
Acute Respiratory Failure-I
1.0K
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
1.0K
Acute Respiratory Failure-II
1.1K
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.1K
Acute Respiratory Failure-V
507
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
507
