没有证据表明FOXP2在不同人群中的近期选择
Elizabeth Grace Atkinson1, Amanda Jane Audesse2, Julia Adela Palacios3
1Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY, USA.
Cell
|August 7, 2018
概括
对于人类说话至关重要的FOXP2基因, 相反,一个保存的内部区域表明功能丧失,修改了它的进化历史.
科学领域:
- 人类的进化
- 遗传学
- 分子生物学
背景情况:
- 福克斯P2基因与人类的语言和进化有关.
- 之前的研究表明近期对人类的FOXP2产生了积极选择.
- 这与古人类的FOXP2替代发现相矛盾.
研究的目的:
- 在大量多样化的基因组数据中重新分析FOXP2.
- 在FOXP2上测试最近的阳性或平衡选择.
- 为了研究FOXP2的进化史.
主要方法:
- 在数百个人类基因组中对FOXP2进行了全面的重新分析.
- 测试最近的阳性和平衡选择.
- 对内部区域进行保护和多态性分析.
- 用于基因表达分析的RNA测序 (RNA-seq) 和逆转录PCR (RT-PCR).
主要成果:
- 没有发现最近对FOXP2的积极或平衡选择的证据.
- 最初的选择信号归因于样本的组成.
- 一个内部区域显示出高的保存和人类多态性,表明功能丧失.
- 这一区域在人类大脑组织中表现较低.
结论:
- 对于FOXP2的适应史,需要进行大量的修改.
- 人类进化中的FOXP2的作用可能涉及功能损失而不是积极选择.
- 这些发现挑战了FOXP2作为人类语言演化的关键驱动器的既定叙述.
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