在小鼠自闭症模型中,核中释放的5-HT 挽救了社会缺陷
Jessica J Walsh1, Daniel J Christoffel1, Boris D Heifets2
1Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Nature
|August 10, 2018
概括
改变小鼠特定脑细胞释放的血清素会对社会行为产生双向影响. 这一发现为自闭症谱系障碍提供了新的治疗目标.
科学领域:
- 神经科学
- 遗传学
- 行为科学
背景情况:
- 自闭症谱系障碍 (ASD) 的特点是社会互动缺陷.
- 社交能力的基本神经机制在很大程度上是未知的,阻碍了有效治疗的发展.
研究的目的:
- 调查中 (5-HT) 信号在调节社会行为的作用.
- 探索与自闭症相关的基因变异对5-HT通路和社交性的影响.
主要方法:
- 使用小鼠模型对16p11.2染色体的合成区域进行删除,这是自闭症的遗传原因.
- 使用光遗传学来调节背部的5-HT神经元活动.
- 评估社会行为和测量5-HT神经元活动.
主要成果:
- 在5-HT神经元中的遗传删除损害了社会行为,并减少了神经元活动.
- 这种社会缺陷的原因是背部5HT神经元的光遗传激活.
- 这种救援效应依赖于并模仿了核中5-HT1b受体的激活.
结论:
- 从背部拉菲神经元释放的氨酸作用于核,在调节社会行为方面发挥着关键作用.
- 向于核中5-HT通路可能为自闭症的社会缺陷提供一种新的治疗策略.
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