乳腺结节的拉链可以防止饮食引起的肥胖
Feng Zhang1, Georgia Zarkada1, Jinah Han1
1Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06510-3221, USA.
概括
通过删除Neuropilin1 (Nrp1) 和血管内皮生长因子受体1 (Vegfr1) 来防止乳类动物的胆米克朗吸收,可以防止饮食引起的肥胖. 这表明乳汁结是控制饮食脂肪吸收的关键目标.
科学领域:
- 血管生物学
- 代谢疾病
- 胃肠病学
背景情况:
- 肥胖是由于饮食中的脂肪摄入过多而导致的.
- 饮食中的脂质被肠细胞吸收,并通过乳细胞运输到血液中.
研究的目的:
- 调查神经1 (Nrp1) 和血管内皮生长因子受体1 (Vegfr1) 在乳汁中胆米克朗吸收中的作用.
- 通过调节肠道脂质吸收来预防饮食引起的肥胖的潜在治疗目标.
主要方法:
- 在小鼠中诱导Nrp1和Vegfr1的内皮遗传缺失.
- 基洛米克朗传输和乳腺结合完整性的分析.
- 研究VEGF-A信号通路的作用,包括VEGFR2和VE-cadherin.
主要成果:
- 在小鼠中,Nrp1和Vegfr1的遗传删除可以预防饮食引起的肥胖.
- 缺少Nrp1和Vegfr1导致乳腺结合的拉链和基洛米克朗的吸收不良.
- 通过VEGFR2和VE-cadherin信号抑制恢复乳腺连接的透性.
- 由于VE-cadherin分解而引起的乳腺结合拉链,在野生类型的小鼠中阻止了基洛米克龙的吸收.
结论:
- 乳腺结点对于基洛米克朗的吸收至关重要.
- NRP1和FLT1信号通道调节乳腺结的透性.
- 针对乳腺结节提供了一种预防饮食脂肪吸收和肥胖的新方法.
相关概念视频
Obesity
1.4K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.4K
P-N junction
1.3K
A p-n junction is formed when p-type and n-type semiconductor materials are joined together. At the interface of the p-n junction, holes from the p-side and electrons from the n-side begin to diffuse into the opposite sides due to the concentration gradient. This diffusion of carriers leads to a region around the junction where there are no free charge carriers, known as the depletion region. The charge density within the depletion region for the n-side and p-side can be described by the...
1.3K
Protection of Alcohols
8.1K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
8.1K
Zones of Protection
808
In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
808
Radial System Protection
445
Radial systems employ time-delay overcurrent relays to reduce load interruptions. When a fault occurs, the nearest breaker opens first, while upstream breakers remain closed due to longer delay settings. This approach ensures minimal disruption to the rest of the system.
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
445
Protecting Self-Esteem
218
Self-esteem, a central component of psychological well-being, is actively maintained through various cognitive and behavioral strategies. Individuals employ specific mechanisms to preserve a positive self-concept and mitigate threats to their self-worth, particularly in contexts involving social evaluation or personal feedback. Four primary techniques are commonly used to sustain self-esteem.Manipulating AppraisalsOne prominent strategy involves manipulating appraisals from others. Individuals...
218


