细胞亡通过细胞质传播作为触发波
Xianrui Cheng1, James E Ferrell2,3
1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA.
概括
编程细胞死亡或细胞亡通过自再生触发波在Xenopus蛋的提取物和细胞传播. 这些波以每分钟30微米的速度传播, 对于细胞信号和组织平衡至关重要.
科学领域:
- 细胞生物学
- 发育生物学
- 生物化学
背景情况:
- 细胞亡是动物发育和平衡中必不可少的细胞死亡.
- 核突网络可能涉及正反循环,使触发波能够自我再生.
- 了解这些机制是细胞信号的关键.
研究的目的:
- 通过无细胞提取物和完整细胞的触发波来调查亡的传播.
- 确定涉及波传播的分子组件和反环.
- 为了确定这些亡波的速度和特征.
主要方法:
- 使用无细胞Xenopus laevis蛋提取物的实验.
- 分割和抑制剂研究以确定关键成分.
- 在apoptotic卵细胞和卵子中观察表面波.
- 与酶激活的相关性分析.
主要成果:
- 在Xenopus蛋提取物中观察到亡的触发波,速度约为每分钟30微米.
- 多个反循环与波产生有关.
- 完整的Xenopus卵细胞和卵在相似的速度显示相关的表面波和酶激活.
- 在这两种系统中,被证明亡是通过触发波传播的.
结论:
- 细胞灭绝通过自我再生的触发波在无细胞的提取物和完整的细胞传播.
- 这些波对于细胞内距离的亡是至关重要的.
- 触发波是细胞信号传递和生物过程中的基本机制.
更多相关视频
09:36Continuous-Wave Propagation Channel-Sounding Measurement System - Testing, Verification, and Measurements
Published on: June 25, 2021
3.5K
10:46Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
Published on: July 16, 2013
16.7K
相关概念视频
Propagation of Waves
3.0K
When a wave propagates from one medium to another, part of it may get reflected in the first medium, and part of it may get transmitted to the second medium. In such a case, the interface of the two mediums can be considered as a boundary that is neither fixed nor free.
Consider a scenario where a wave propagates from a string of low linear mass density to a string of high linear mass density. In such a case, the reflected wave is out of phase with respect to the incident wave, however the...
Consider a scenario where a wave propagates from a string of low linear mass density to a string of high linear mass density. In such a case, the reflected wave is out of phase with respect to the incident wave, however the...
3.0K
Propagation Speed of Electromagnetic Waves
4.7K
Electromagnetic waves are consistent with Ampere's law. Assuming there is no conduction current Ampere's law is given as:
4.7K
Cytoplasm
89.9K
The cytoplasm consists of organelles and a framework of protein scaffolds called the cytoskeleton suspended in an aqueous solution, the cytosol. The cytosol is a rich broth of water, ions, salts, and various organic molecules.
Protein Folding and Misfolding
The cytoplasm is the location for several cellular processes, including protein synthesis and folding. The aqueous nature of the cytosol promotes protein folding such that the hydrophobic amino acid side chains are buried in the protein...
Protein Folding and Misfolding
The cytoplasm is the location for several cellular processes, including protein synthesis and folding. The aqueous nature of the cytosol promotes protein folding such that the hydrophobic amino acid side chains are buried in the protein...
89.9K
Cytoplasm
8.4K
The cytoplasm consists of organelles and a framework of protein scaffolds called the cytoskeleton suspended in an aqueous solution, the cytosol. The cytosol is a rich broth of water, ions, salts, and various organic molecules.
Protein Folding and Misfolding
The cytoplasm is the location for several cellular processes, including protein synthesis and folding. The aqueous nature of the cytosol promotes protein folding such that the hydrophobic amino acid side chains are buried in the protein...
Protein Folding and Misfolding
The cytoplasm is the location for several cellular processes, including protein synthesis and folding. The aqueous nature of the cytosol promotes protein folding such that the hydrophobic amino acid side chains are buried in the protein...
8.4K
The Wave Nature of Light
61.5K
The nature of light has been a subject of inquiry since antiquity. In the seventeenth century, Isaac Newton performed experiments with lenses and prisms and was able to demonstrate that white light consists of the individual colors of the rainbow combined together. Newton explained his optics findings in terms of a "corpuscular" view of light, in which light was composed of streams of extremely tiny particles traveling at high speeds according to Newton's laws of motion.
61.5K
Apoptosis
15.2K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
15.2K
