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相关概念视频

Functional Groups02:45

Functional Groups

89.0K
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
89.0K
Functional Groups02:45

Functional Groups

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24.5K
Functionalism01:11

Functionalism

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William James, John Dewey, and Charles Sanders Peirce were instrumental in founding functional psychology, which draws heavily from Darwin's theory of evolution by natural selection. This theory suggests that individual traits, including behaviors, are adapted to their environments through natural selection. At the heart of functionalism is the concept of adaptation, meaning that a trait enhances an individual's chances of survival and reproduction.
James envisioned psychology's...
2.6K
Mechanical Protein Functions01:58

Mechanical Protein Functions

5.6K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
5.6K
Structural Protein Function01:56

Structural Protein Function

30.0K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
30.0K
Hyperbolic Functions01:25

Hyperbolic Functions

72
A flexible cable suspended between two points at the same height naturally forms a curve known as a catenary. This shape results from the balance between the cable’s weight and the tension acting along its length, representing a state of mechanical equilibrium. Unlike simpler approximations, the true shape of a hanging cable is described using hyperbolic functions.Hyperbolic functions are closely related to exponential functions and are named for their connection to the geometry of the...
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相关实验视频

Updated: Feb 6, 2026

mirMachine: A One-Stop Shop for Plant miRNA Annotation
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mirMachine: A One-Stop Shop for Plant miRNA Annotation

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快照:非常规的miRNA功能

Mihnea Paul Dragomir1, Erik Knutsen1, George Adrian Calin1

  • 1Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

Cell
|August 11, 2018
PubMed
概括

微RNAs (miRNAs) 通常抑制基因表达. 本综述探讨了miRNAs通过超出标准的转录后抑制的非传统调节机制起作用的新证据.

科学领域:

  • 分子生物学
  • 遗传学
  • 表观遗传学

背景情况:

  • 微RNAs (miRNAs) 是已知的基因表达的调节者.
  • 它们的正规功能涉及对象信使RNA的转录后抑制.
  • 最近的发现表明miRNAs具有替代的调节作用.

研究的目的:

  • 总结和突出显示微RNA的非正规功能.
  • 提供超越基因沉默的miRNA调节机制的概述.
  • 巩固目前关于非传统miRNA活动的知识.

主要方法:

  • 最近科学研究的文献评论.
  • 对miRNA功能报告的实验证据的分析.
  • 综合各种miRNA调节途径的发现.

主要成果:

  • 识别多种非常规的miRNA调节机制.
  • 作为转录激活剂或抑制剂的miRNAs的例子.
  • 参与非编码RNA调节和其他途径的miRNA的证据.

结论:

  • 微RNA表现出比以前理解的更广泛的调节功能.

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  • 这些非传统的作用扩大了基因调节的复杂性.
  • 需要进一步的研究来充分阐明这些新的miRNA功能.