增强治疗:时间到了
1Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Cell
|August 11, 2018
概括
饮食引起的肥胖会通过影响昼夜基因增强剂改变日常生理节奏. 药物的有效性,特别是降脂药物,随着服用时间而变化.
科学领域:
- 时间生物学
- 代谢疾病
- 肥胖研究
背景情况:
- 饮食,肥胖和日常生理节奏之间的相互作用尚未完全理解.
- 循环基因调节在新陈代谢过程中起着至关重要的作用.
研究的目的:
- 研究饮食和肥胖如何影响白天的生理变化.
- 确定肥胖对昼夜基因增强者的影响.
- 评估依赖时间的降脂药物的疗效.
主要方法:
- 使用饮食诱导的肥胖模型.
- 分析了昼夜基因增强剂的活性.
- 研究药物给药时间对脂质代谢的影响.
主要成果:
- 发现饮食诱导的肥胖会调节昼夜基因增强剂的活性.
- 调节脂质代谢的特定增强剂受到影响.
- 降脂药物的疗效显著依赖于每天的时间.
结论:
- 肥胖会破坏人体的日常节律,
- 针对脂质代谢的治疗策略可以通过考虑药物使用时间来优化.
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