在布基纳法索农村地区,Olyset Duo含有pyriproxyfen和perethrin的床网与仅含有perethrin的床网对临床疟疾的有效性:一个集群随机对照试验
Alfred B Tiono1, Alphonse Ouédraogo1, Daouda Ouattara1
1Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso.
Lancet (London, England)
|August 15, 2018
概括
在布基纳法索, 结合甲基和氧的新床网显著减少了临床疟疾的发生. 这提供了一个有希望的替代标准杀虫网的高耐药性.
科学领域:
- 热带医学
- 昆虫学
- 公共卫生
背景情况:
- 在撒哈拉以南的非洲, 长效杀虫网 (LLIN) 已经减少了疟疾.
- 疟疾载体中的甲状腺耐药性威胁到LLIN的有效性.
- 布基纳法索面临着严重的疟疾传播和抗甲状腺病毒的传播媒介.
研究的目的:
- 评估含有甲基氨酸和pyriproxyfen (PPF) 的LLIN与仅含甲基氨酸的标准LLIN的有效性.
- 对布基纳法索5岁以下儿童的临床疟疾保护进行评估.
主要方法:
- 一个两组,阶段,集群随机对照试验.
- 在40个农村集群中,LLIN被PPF处理的LLIN逐渐取代.
- 临床疟疾发病率和昆虫疫苗接种率是主要终点.
主要成果:
- 接受PPF治疗的LLIN组显示临床疟疾发病率降低了12% (IRR为0. 88, p=0. 04).
- 在PPF治疗的LLIN组中,昆虫学接种率下降了一半 (率比为0.49,p<0.0001).
- 超过99%的儿童使用了提供的床网.
结论:
- 与标准LLIN相比,用PPF处理的LLIN对临床疟疾提供了更好的保护.
- 这些网在疟疾传播率高的地区和抗甲状腺病毒传播者中是一个可行的替代方案.
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