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使用升级纳米粒子观察,定位和交付

Ghulam Jalani1, Vivienne Tam1, Fiorenzo Vetrone2

  • 1Department of Mining and Materials Engineering , McGill University , Montreal , Quebec H3A 0C5 , Canada.

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PubMed
概括
此摘要是机器生成的。

上转化纳米粒子 (UCNPs) 能够使用近红外 (NIR) 光触发深层组织的药物输送. 这克服了UV/Vis光的局限性,用于精确,非侵入性的治疗应用.

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科学领域:

  • 纳米技术和生物医学工程
  • 光药学和药物输送系统

背景情况:

  • 有效的药物释放控制对于提高治疗效果和最大限度地减少副作用至关重要.
  • 目前的光触发药物输送系统受到UV/Vis光的组织透和潜在毒性限制.
  • 通过将更深入的近红外 (NIR) 光转换为更短的波长,上转换纳米粒子 (UCNPs) 提供了一个解决方案.

研究的目的:

  • 审查基于UCNP的光控制药物输送系统的最新进展.
  • 讨论这些技术所面临的挑战,并提出临床转化解决方案.
  • 突出NIR触发的UCNP在精确的,非侵入性的治疗应用中的潜力.

主要方法:

  • 使用UCNP吸收近红外辐射 (NIR).
  • 将被吸收的NIR光转化为更短波长的UV,可见光或NIR辐射.
  • 使用这些排放触发局部药物释放和生物成像.

主要成果:

  • UCNP使药物释放由NIR光触发,这种光比UV/Vis光更深入地穿透组织.
  • 这种方法允许精确的,按需的药物输送到体内的特定位置.
  • 在药物释放和生物成像应用中,UCNPs作为有效的现场光源.

结论:

  • 通过UCNP介导的NIR触发的药物输送系统比传统的光控制方法具有显著的进步.
  • 这些系统有望在麻醉,伤口愈合,手术和癌症治疗方面发挥作用.
  • 需要进一步的研究和开发,以促进基于UCNP的药物输送的临床转化.