多功能催化对玻利功能化全碳四度性立体中心的选择性输入
1Department of Chemistry , National University of Singapore , 3 Science Drive 3 , Singapore 117543 , Singapore.
Journal of the American Chemical Society
|August 17, 2018
概括
研究人员开发了一种使用催化剂的全碳四元立体中心制造性基功能化γ-乳酸盐的新方法. 这一突破使得各种性乳酸和相关化合物的合成成为可能.
科学领域:
- 有机化学
- 不对称的合成
- 催化剂
背景情况:
- 基拉尔γ- lactams是药物化学中的重要组成部分.
- 构建全碳四元立体中心的高效方法非常受欢迎.
- 复杂有机分子的不对称合成仍然是一个重大挑战.
研究的目的:
- 开发一种新型的非对称合成利功能化γ- lactams.
- 建立一个全碳四元立体中心的方法.
- 探索获得的产品的合成实用性.
主要方法:
- 催化酶选择性化/循环反应
- 作为基质使用胺结的1,6-.
- 随后的奇拉性γ-乳酸产品的转化.
主要成果:
- 通过全碳四元立体中心成功合成了性基功能化γ-乳酸盐.
- 在化/循环化过程中获得高反选择性.
- 证明了产品易于转化为各种性乳酸,pyrrolidin-2,3-diones和β-氨基酸衍生物.
结论:
- 开发的同催化反应提供了一条有效的途径,以化丰富的γ- lactams.
- 这种方法为进一步的合成应用提供了有价值的性中间体.
- 这项研究扩大了含复杂异环的不对称合成工具箱.
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