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Controlled Cortical Impact Model for Traumatic Brain Injury
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创伤性脑损伤与自杀风险之间的联系
Trine Madsen1,2, Annette Erlangsen1,3,4,5, Sonja Orlovska2
1Danish Research Institute of Suicide Prevention, Mental Health Centre Copenhagen, Capital Region of Denmark, Copenhagen, Denmark.
JAMA
|August 19, 2018
概括
患有创伤性脑损伤 (TBI) 的人面临自杀的风险明显更高. 这种风险随着TBI医疗接触的严重程度和频率而增加,特别是在受伤后不久.
科学领域:
- 神经科学
- 公共卫生
- 流行病学
背景情况:
- 创伤性脑损伤 (TBI) 与长期的精神问题有关.
- 需要进一步调查伤心和自杀风险之间的联系.
研究的目的:
- 调查创伤性脑损伤和随后的自杀风险之间的联系.
主要方法:
- 一项回顾性队列研究使用了1980年至2014年的丹麦全国性注册表.
- 包括超过740万个人 (≥10年),其中有567823人因TBI与医生接触.
- Poisson回归分析了自杀风险, 调整了骨折,精神病诊断和自我伤害等共变量.
主要成果:
- 与没有TBI的人相比,TBI患者的自杀率几乎增加了两倍 (IRR为1.90).
- 严重的TBI显示出与自杀相关的最高风险 (IRR为2. 38).
- 自杀风险随着TBI接触人数的增加而升级,并且在受伤后的六个月内最高 (IRR为3.67).
结论:
- 有关TBI的医疗接触与增加自杀风险有关.
- 风险取决于TBI的严重程度和医疗接触的频率.
- 时间接近TBI诊断显著增加了自杀风险.
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