基于激发和发射波长的多重光谱,使用红色吸收近红外发射兰化物复合物
Ruisheng Xiong1, Dimitrije Mara2, Jing Liu2
1Department of Chemistry, Ångström Laboratory , Uppsala University , Lägerhyddsvägen 1 , 75120 Uppsala , Sweden.
Journal of the American Chemical Society
|August 21, 2018
概括
新的兰化物复合物使红色和近红外 (NIR) 生物区域的高级多重成像成为可能. 这一突破克服了目前的局限性, 允许实时, 多色生物系统的调查.
科学领域:
- 生物医学成像
- 摄影化学
- 材料科学
背景情况:
- 红色和近红外 (NIR) 频谱的多重成像对于实时生物研究至关重要.
- 现有的发射器寿命短,光谱带宽,斯托克斯转移小,限制多色化到两种颜色.
- 兰化物 (Ln) 复合物与化物 () 敏感剂具有改善NIR发射的潜力.
研究的目的:
- 开发用于增强多重成像的新型NIR发射化物复合物.
- 克服目前红色和NIR区域的排放者的局限性
- 通过激发和排放复杂化使生物样本能够进行多色差异化.
主要方法:
- 合成的NIR发射兰坦化物复合物,使用烯 () 天线功能化.
- 在红色光谱中利用狭窄,强烈和可调的吸收.
- 探索了基于发射的多重复合 (相同天线的不同Ln) 和基于激发的多重复合 (相同Ln上的不同).
主要成果:
- 证明了多重化多达四种不同化物复合物的可行性
- 展示了使用激发和辐射光谱的组合来区分复合物的能力.
- 与目前可用的NIR发射器相比,获得了更好的光谱特性.
结论:
- 具有天线的兰化物复合体代表了红色和NIR多重成像的重大进步.
- 这种方法克服了光谱的局限性,使更复杂的实时生物研究成为可能.
- 开发的复合体为先进的生物成像应用提供了多功能平台.
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