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Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR
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通过TUT4/7的尿化限制了人类LINE-1s的逆转换

Zbigniew Warkocki1, Paweł S Krawczyk2, Dorota Adamska2

  • 1Laboratory of RNA Biology and Functional Genomics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106 Warsaw, Poland.

Cell
|August 21, 2018
PubMed
概括

通过向LINE-1mRNA添加尿素来控制LINE-1的逆转换. 这种由 TUT4 和 TUT7 酶引起的尿基化限制了 LINE-1 的活性,从而保持了基因组的稳定性.

关键词:
3′ RACE-seq 时间一个L1-ORF1p其他类型一号线MOV10 时间其他国家美国其他类型反转换尿化

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