尿液中的分泌,血压,心血管疾病和死亡率:社区一级的前性流行病学队列研究
Andrew Mente1, Martin O'Donnell2, Sumathy Rangarajan3
1Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada; Department of Health Research Methods, McMaster University, Hamilton, ON, Canada.
Lancet (London, England)
|August 22, 2018
概括
减少高摄入量可以预防心血管疾病,特别是在每天摄入5g以上的社区. 降低这些人群中的含量,
科学领域:
- 心脏病学
- 公共卫生
- 流行病学
背景情况:
- 世界卫生组织 (WHO) 建议每天摄入不到2克的来预防心血管疾病 (CVD).
- 这项建议是基于血压数据,缺乏对心血管疾病事件的随机试验的证据.
- 之前的研究没有明确地确定低摄入量与心血管事件的减少之间的联系.
研究的目的:
- 研究社区平均和摄入量与心血管疾病 (CVD) 和死亡率之间的关联.
- 检查饮食中的与血压 (BP) 之间的关系.
- 为改进全球摄入量建议提供证据.
主要方法:
- 对18个国家的前性城市农村流行病学 (PURE) 研究数据的分析.
- 包括35至70岁的95,767名没有心血管疾病的成年人.
- 使用早晨禁食尿样评估24小时内和分泌量.
- 评估/摄入量与血压,心血管疾病和死亡率之间的社区水平关联,并对个人水平的混因素进行调整.
主要成果:
- 平均静脉压 (BP) 随着摄入量增加而增加,特别是在摄入量最高的社区 (> 5. 08 g/ day).
- 心血管事件与摄入量有非线性关联,在最低三位数 (< 4. 43 g/ day) 中有显著的反向关联,在中间三位数 (4. 43- 5. 08 g/ day) 中没有关联.
- 在所有国家,增加摄入量与心血管结果的降低有关. 在中国,中风发病率与高摄入量有很强的关联.
结论:
- 摄入与心血管疾病和中风有关,主要是在平均摄入量超过5g/天的社区.
- 在高摄入量的社区,有针对性的减少的策略可能比普遍的建议更合适.
- 增加饮食摄入量似乎对全球心血管健康有益.
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