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Updated: Feb 6, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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RAP2介导Hippo通路的机械反应

Zhipeng Meng1, Yunjiang Qiu2,3, Kimberly C Lin1

  • 1Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.

Nature
|August 24, 2018
PubMed
概括

与Ras相关的GTPase RAP2作为一个分子开关,通过Hippo途径效应器YAP和TAZ传递细胞外矩阵刚性信号来控制细胞生长和基因转录.

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