包装 pDNA 通过聚合物 ABC 微粒同时实现合体稳定性和结构控制

Yaming Jiang1, Timothy P Lodge1,2, Theresa M Reineke2

  • 1Department of Chemical Engineering & Materials Science , University of Minnesota , 421 Washington Avenue SE , Minneapolis , Minnesota 55455 , United States.

概括

使用带电纳米颗粒的DNA压缩是治疗的关键. 研究人员发现,将聚乙烯糖醇 (PEG) 冠状体添加到聚合物细胞中,显著改善了DNA复合体的稳定性和受控的细胞结构,产生了仿生色素样形式.

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