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Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System
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Published on: April 11, 2025

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在发育和衰老过程中抑制RIPK1驱动的亡和炎症

Daichao Xu1, Taijie Jin2, Hong Zhu1

  • 1Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.

Cell
|August 28, 2018
PubMed
概括

衰老通过减少TAK1而加剧神经退行,而TAK1会激活RIPK1. 这种与TBK1损失等遗传因素的相互作用促进了肌缩侧面硬化和前性痴呆.

关键词:
美国一个FTD一个RIPK在RIPK1依赖的亡时间一个TBK1类植物尸体死亡

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