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Updated: Feb 6, 2026

Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites
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Published on: January 3, 2011

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疟疾寄生虫转位体结构和效应体输出机制

Chi-Min Ho1,2,3, Josh R Beck4,5,6, Mason Lai2

  • 1The Molecular Biology Institute, University of California, Los Angeles, CA, USA.

Nature
|August 29, 2018
PubMed
概括

在结构上揭示出口蛋白质的Plasmodium转位子 (PTEX),揭示出出口疟疾效应蛋白的机制. 这一发现为开发针对这种重要寄生虫出口系统的药物提供了新的途径.

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Nuclear Export01:42

Nuclear Export

The nucleus restricts several proteins within and allows others to pass. The restricted proteins possess a nuclear retention sequence or NRS, anchoring them to the nuclear lamins and preventing their transport to the cytosol. The non-restricted proteins, after their synthesis, are transported to their site of action, such as the cytosol or other organelles, with the help of nuclear export signals or NES.
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Nuclear Export of mRNA02:31

Nuclear Export of mRNA

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Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
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