用阿司匹林降低心血管疾病中等风险患者初始血管事件的风险 (ARRIVE):随机,双盲,安慰剂对照试验
在PubMed上查看摘要
概括
此摘要是机器生成的。在中度风险患者中,阿司匹林没有显著减少心血管事件. 然而,阿司匹林使用与胃肠道出血的发生率较高有关,这表明在初级预防策略中应谨慎.
科学领域
- 心脏病学
- 预防医学
- 临床试验
背景情况
- 阿司匹林在心血管事件的初级预防中的作用受到争议.
- 在中度风险患者中评估阿司匹林的疗效和安全性至关重要.
研究的目的
- 评估阿司匹林与安慰剂对心血管事件的初级预防.
- 确定阿司匹林在这个群体中的安全性.
主要方法
- 随机,双盲,安慰剂对照试验 (ARRIVE研究).
- 患有中等心血管风险的55岁以上 (男性) 或60岁以上 (女性) 的患者.
- 每天服用阿司匹林 (100毫克) 或安慰剂,平均持续时间为60个月.
主要成果
- 在阿司匹林和安慰剂组之间没有显著的差异 (心血管死亡,心脏病发作,不稳定的心痛,中风,TIA) (4. 29% vs 4. 48%).
- 在阿司匹林组中,胃肠道出血事件显著增加 (0. 97% vs 0. 46%).
- 整体严重不良事件和死亡率在各组之间相似.
结论
- 由于事件发生率低于预期,该研究无法证实阿司匹林对中度风险患者的初级预防有益.
- 结果与之前的低风险初级预防研究一致,没有显著的疗效,但增加了出血风险.
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