酒精使用障碍的诊断和药物治疗:一篇综述
Henry R Kranzler1,2, Michael Soyka3,4
1Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia.
JAMA
|September 1, 2018
概括
常规查酒精使用障碍 (AUD) 建议但未得到充分利用. 有效的治疗方法,包括纳尔特雷等药物, 但对AUD患者的处方不足.
科学领域:
- 医学研究
- 公共卫生
- 药理学
背景情况:
- 酒精消费导致美国的死亡率和发病率显著.
- 酒精使用障碍 (AUD) 每年影响高达14%的美国成年人.
- 只有不到8%的AUD患者接受治疗,只有六分之一的成年人接受医疗专业人员的查.
研究的目的:
- 强调过度饮酒和AUD查的重要性.
- 审查美国食品和药物管理局批准的AUD治疗药物.
- 为了强调有效的AUD治疗方法的不足.
主要方法:
- 对AUD查和治疗的现有文献和临床指南的审查.
- 对AUD药物的疗效和处方率的分析.
- 讨论当前的治疗缺口和建议.
主要成果:
- 过度饮酒是AUD的主要危险因素.
- 美国食品和药物管理局已批准四种药物 (二硫,纳尔特雷,阿卡姆普罗沙特) 用于治疗AUD.
- 药物被处方给不到9%的可能受益的患者,
结论:
- 过度饮酒的查可以识别患者进行AUD评估.
- 建议对AUD进行简短的咨询和第一线药物治疗.
- 增加查和药物处方对于管理AUD至关重要.
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