具有前所未有的抗菌效率和治疗指数的工程聚合物纳米粒子对抗多药耐药细菌和生物膜
Akash Gupta1, Ryan F Landis1, Cheng-Hsuan Li1
1Department of Chemistry , University of Massachusetts Amherst , 710 North Pleasant Street , Amherst , Massachusetts 01003 , United States.
Journal of the American Chemical Society
|September 1, 2018
概括
新的聚合物纳米粒子有效地对抗抗生素耐药的超级细菌和生物膜. 这些新型抗菌剂没有出现耐药性发展,为传统抗生素提供了有希望的替代品.
科学领域:
- 生物材料科学
- 传染性疾病
- 纳米技术
背景情况:
- 抗生素耐药的细菌或"超级细菌"对全球健康构成严重威胁.
- 患有抗生素耐药生物膜的慢性感染尤其难以治疗.
- 由于高死亡率和抗药性发展,现有的治疗方法往往失败.
研究的目的:
- 设计具有强大抗菌性能的合成聚合物纳米粒子.
- 研究这些纳米粒子对抗抗生素耐药细菌和生物膜的有效性.
- 评估对新型纳米颗粒的抗药性发展的可能性.
主要方法:
- 半刚性聚合物支架的设计和合成,包括疏水性和离子性领域.
- 制造用于抗菌剂的聚合物纳米粒子.
- 在体外对抗抗生素耐药性细菌菌株和生物膜进行检测.
- 对哺乳动物细胞和红细胞的细胞毒性评估.
- 连续通过实验以评估耐药性的发展.
主要成果:
- 开发的聚合物纳米颗粒显示出高效的抗菌活性.
- 有效地消除了抗生素耐药的生物膜.
- 纳米颗粒对哺乳动物细胞的毒性较低,对红细胞的治疗指数较高.
- 不同于常规抗生素,在20次连续治疗后没有产生细菌耐药性.
结论:
- 工程化聚合物纳米颗粒代表了对抗生素耐药细菌和生物膜的新有效策略.
- 设计的纳米颗粒为目前的抗生素提供了有希望的替代品, 具有较低的耐药性风险.
- 这种方法对抗抗菌素耐药性的全球威胁具有重大潜力.
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