光线通过视网膜和大脑的不同通路影响情绪和学习
Diego Carlos Fernandez1, P Michelle Fogerson2, Lorenzo Lazzerini Ospri3
1Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
Cell
|September 4, 2018
概括
轻的
科学领域:
- 神经科学
- 眼科 眼科
- 时间生物学
背景情况:
- 光显著影响情绪和学习,由内在光敏感视网膜质细胞 (ipRGC) 介导.
- 这些光诱导效应的特定神经通路和中央介质在很大程度上是未知的.
研究的目的:
- 阐明通过内在光敏感视网膜质细胞 (ipRGCs) 调节情绪和学习的独特神经回路.
- 确定光对认知功能和情感行为影响的核心媒介.
主要方法:
- 研究了不同的ipRGC输出路径.
- 使用神经解剖学跟踪和行为分析来绘制光感应路径.
- 检查了上核 (SCN) 和新发现的乳头区域 (周围核,PHb) 的作用.
主要成果:
- 光对学习的影响是由ipRGCs投射到上神经核 (SCN) 介导的,独立于其节拍器的作用.
- 通过光调节情绪,涉及从ipRGC到周围细胞核 (PHb) 的SCN独立路径.
- 周周核 (PHb) 对于调解光对情感行为的影响至关重要,将ipRGC与情绪中心连接起来.
结论:
- 不同的ipRGC输出流不同调节学习和情绪.
- 超神核 (SCN) 参与光介导的学习,而光介导核 (PHb) 是光对情绪影响的关键.
- 这项研究揭示了光线如何影响认知和情绪的新型神经基质.
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