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Updated: Feb 5, 2026

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在多发性硬化症中,记忆B细胞激活大脑的自动反应性CD4+T细胞

Ivan Jelcic1, Faiez Al Nimer2, Jian Wang1

  • 1Neuroimmunology and MS Research Section (NIMS), Neurology Clinic, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland.

Cell
|September 4, 2018
PubMed
概括

多发性硬化症涉及遗传和环境因素. 这项研究表明HLA-DR15阳性患者的T细胞自我反应率升高,由B细胞介导,并确定了脑特异性自身抗原RASGRP2.

关键词:
B 单元格HLA-DR15的使用其他类型T细胞受体一个T细胞自我扩散大脑多发性硬化症疾病的发生

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