癌前瘤细胞可以通过胰腺管道系统移动
Alvin P Makohon-Moore1, Karen Matsukuma2, Ming Zhang3
1The David M. Rubenstein Center for Pancreatic Cancer Research, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nature
|September 5, 2018
概括
胰腺癌的进展涉及多年来的前体病变. 遗传分析显示,一个胰腺的不同病变往往来自于一个瘤,
科学领域:
- 癌症学
- 遗传学
- 进化生物学
背景情况:
- 大多数成年癌症是由非侵入性前体病变引起的.
- 同时存在的病变之间的进化和遗传联系仍然不太清楚.
研究的目的:
- 研究胰腺癌及其前体病变之间的进化和遗传关系.
- 为了重新构建胰腺癌的逐步进展模型.
主要方法:
- 对来自不同胰腺区域的胰腺癌和前体病变的体质变异分析.
- 在病变之间推断进化关系.
主要成果:
- 确定一个祖先细胞开始并以克隆方式扩展,形成多种病变.
- 随后的驱动基因突变导致了多年来侵袭性胰腺癌.
- 单个胰腺中的明显的高度前体病变通常代表单个瘤已经殖民于管道系统.
结论:
- 胰腺癌在长时间内通过多个阶段的进展发展.
- 单个胰腺内的独立前体病变可能源于常见的瘤来源.
- 这项研究重塑了人们对胰腺癌演变和空间遗传差异的理解.
相关概念视频
Pancreatic Juice and Secretion
3.0K
Pancreatic juice is a clear fluid produced by the pancreas, containing water, salts, sodium bicarbonate, and enzymes vital for digestion in the small intestine. It helps break down large molecules, facilitating nutrient absorption.
When acidic chyme from the stomach enters the duodenum, it triggers the release of secretin, a hormone that prompts pancreatic juice secretion. After a fatty meal, cholecystokinin, another hormone, stimulates gallbladder contraction and enhances enzyme-rich...
When acidic chyme from the stomach enters the duodenum, it triggers the release of secretin, a hormone that prompts pancreatic juice secretion. After a fatty meal, cholecystokinin, another hormone, stimulates gallbladder contraction and enhances enzyme-rich...
3.0K
Acute Pancreatitis I: Introduction
1.3K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.3K
Chronic Pancreatitis I: Introduction
745
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
745
Chronic Pancreatitis II: Collaborative Care
373
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
373
Acute Pancreatitis II: Clinical Manifestations and Management
877
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
877
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
2.6K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
Insulin and C-peptide are...
2.6K


