脊椎动物体轴延长的基础是从液体到固体的阻塞过渡
Alessandro Mongera1,2,3, Payam Rowghanian1,2, Hannah J Gustafson1,2,4
1Department of Mechanical Engineering, University of California, Santa Barbara, CA, USA.
Nature
|September 7, 2018
概括
在脊椎动物的发育过程中,胚胎组织从流体状转变为固体状,这是指导身体轴延长和形态发生的阻塞转变.
科学领域:
- 生物物理
- 发育生物学
- 软物质物理学
背景情况:
- 细胞集体表现出干扰过渡, 在流体和固体行为之间切换.
- 这些干扰现象在二维和三维细胞培养中被观察到,并且在理论上被预测出来.
- 它们的发生和功能作用在体内,特别是在胚胎形态发生过程中,仍然在很大程度上未被探索.
研究的目的:
- 调查脊椎动物胚胎形态发生时是否发生杂过渡.
- 确定这些转换在身体轴延长等过程中的功能作用.
- 阐明发育过程中组织行为背后的物理机制.
主要方法:
- 在体内直接测量组织力学.
- 脊椎动物体轴延长过程中的细胞动态分析.
- 对依赖N-cadherin的产量应力梯度进行量化.
主要成果:
- 脊椎动物的后部组织从流体状 (中皮原生区域) 过渡到固体状 (前皮中皮).
- 在N-cadherin依赖的产量压力中,前后梯度增加了组织的机械完整性.
- 快速的细胞级应力波动使生长端的组织"融化",而持续的细胞上应力则引导形态遗传流.
结论:
- 通过阻塞过渡对流体状和固体状组织状态的时空控制对胚胎形态发生至关重要.
- 这种过渡在体轴延伸过程中为组织重塑和成熟提供机械支持.
- 阻塞过渡是潜在的通用物理机制, 控制胚胎发育.
相关概念视频
Composition of Body Fluids
2.6K
Water functions as a solvent accommodating various solutes, which can be categorized under electrolytes and non-electrolytes. Non-electrolytes are usually held together by covalent bonds, restricting them from dissociating in solution, thereby leading to a lack of electrically charged components upon dissolving in water. They are predominantly organic molecules, such as glucose, creatinine, and urea. Electrolytes, on the other hand, are compounds that can break down into ions in water.
2.6K
Transcription Elongation Factors
14.0K
Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
14.0K
Transcription Elongation Factors
4.8K
4.8K
Phase Transitions
23.2K
Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
23.2K
Body Water Content and Fluid Compartments
4.2K
Life's biochemical processes occur within aqueous solutions. Solutes are substances that are dissolved within these solutions. The human body contains a variety of solutes, which can differ across various body parts. These can encompass proteins—such as those responsible for clotting and carbohydrate transport—as well as electrolytes. In medicine, an electrolyte is often described as a mineral ion derived from a salt possessing an electric charge. Examples include sodium ions...
4.2K
Phase Transitions: Sublimation and Deposition
20.2K
Some solids can transition directly into the gaseous state, bypassing the liquid state, via a process known as sublimation. At room temperature and standard pressure, a piece of dry ice (solid CO2) sublimes, appearing to gradually disappear without ever forming any liquid. Snow and ice sublimate at temperatures below the melting point of water, a slow process that may be accelerated by winds and the reduced atmospheric pressures at high altitudes. When solid iodine is warmed, the solid sublimes...
20.2K


