个性化肠菌殖民 耐实验益生菌与独特的宿主和微生物组特征相关
Niv Zmora1, Gili Zilberman-Schapira2, Jotham Suez2
1Immunology Department, Weizmann Institute of Science, Rehovot, 7610001, Israel; Internal Medicine Department, Tel Aviv Sourasky Medical Center, Tel Aviv, 6423906, Israel.
Cell
|September 8, 2018
概括
益生菌在消化过程中存活下来, 但由于耐药性, 需要个性化的益生菌策略来有效地影响肠道微生物和健康.
科学领域:
- 胃肠病学
- 微生物组研究
- 免疫学
背景情况:
- 益生菌广泛用于健康, 但它们的肠道殖民效果仍有争议.
- 了解益生菌与肠道粘膜的相互作用对于优化它们的使用至关重要.
研究的目的:
- 在小鼠和人类中研究益生菌肠道粘膜殖民的有效性.
- 描述益生菌对肠道微生物组和宿主转录组的影响.
主要方法:
- 对小鼠和人类粘膜相关和便微生物组的基因组分析.
- 在益生菌或安慰剂摄入期间进行侵入性多组体测量.
- 在无细菌和被殖民小鼠中比较殖民抵抗.
主要成果:
- 在胃肠道通过后,益生菌仍然有效.
- 被殖民的小鼠表现出显著的粘膜殖民抵抗益生菌.
- 人类粘膜殖民模式是个体,区域和菌株特有的.
- 益生菌对粘膜社区结构和肠道转录组产生短暂的个性化影响.
结论:
- 实验性益生菌补充剂对肠道粘膜的普遍和持续影响有限.
- 需要个性化的益生菌方法来提高疗效.
- 基线宿主和微生物组特征预测益生菌的殖民模式.
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