追踪大致中和抗体反应的HIV-1菌株
Roger D Kouyos1,2, Peter Rusert3, Claus Kadelka3,4
1Institute of Medical Virology, University of Zurich, Zurich, Switzerland. roger.kouyos@usz.ch.
Nature
|September 12, 2018
概括
感染艾滋病毒的菌株显著影响广泛中和抗体 (bNAbs) 的产生. 识别bNAb印记病毒可能有助于设计有效的HIV疫苗.
科学领域:
- 免疫学
- 病毒学
- 疫苗开发
背景情况:
- 开发基于广泛中和抗体 (bNAb) 的HIV疫苗需要了解推动bNAb演变的因素.
- 虽然bNAb演变的辅因子已知,但感染HIV-1菌株对抗体反应范围和特异性的影响尚不清楚.
- 在自然HIV-1感染期间很少诱导bNAbs.
研究的目的:
- 分析病毒抗原对人类抗体对HIV-1的反应的影响.
- 介绍并提供bNAb印记病毒概念的证据.
- 调查抗体反应的病毒遗传性.
主要方法:
- 分析了53个HIV-1结合和中和抗体反应的参数.
- 对303个具有高度相关性病毒株的HIV-1传播对进行研究.
- 在队列中对bNAb印记病毒进行系统查.
主要成果:
- 感染病毒株对bNAb反应的结果有中等但极为显著的影响.
- 发现了bNAb印记病毒存在的证据.
- 一对传输对表现出相当大的bNAb印记能力,具有类似的HIV-1抗体反应和强烈的bNAb活性.
结论:
- 这些发现支持了bNAb印制病毒的概念.
- 鉴定和描述bNAb印记病毒可能导致新型HIV疫苗免疫原体的开发.
- 了解抗体反应的病毒决定因素对于有效的HIV疫苗设计至关重要.
相关概念视频
Imprinting
11.2K
Behavioral imprinting is observed in some newborn animals and occurs when they develop strong and specific attachments to another animal (usually a parent) following brief, early-life exposures. Offspring imprint onto parents within a brief period after birth or hatching; this time window is called the critical period. Once imprinting occurs, the bond established between the parents and their offspring is usually long-lasting.
11.2K
Genomic Imprinting and Inheritance
37.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.2K
Acids, Bases and Neutralization Reactions
63.8K
An acid-base reaction is one in which a hydrogen ion, H+, is transferred from one chemical species to another. Such reactions are of central importance to numerous natural and technological processes, ranging from the chemical transformations within cells or lakes and oceans to the industrial-scale production of fertilizers, pharmaceuticals, and other substances essential to the society.
63.8K
Acids, Bases and Neutralization Reactions
10.3K
Acids and bases play several important roles in biology. The pH of a biological system can significantly impact the function of biological molecules, including enzymes, proteins, and nucleic acids. For example, enzymes have optimal pH ranges for their activity, and changes in pH can denature or alter their structure, affecting their function. Acids and bases also play a crucial role in cellular signaling and communication. The pH of the extracellular fluid around cells can influence the...
10.3K
Antibody Structure
65.6K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
65.6K
Humoral Immune Responses
84.0K
Overview
84.0K


