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没有可检测的全基因组非目标突变的体内CRISPR编辑

Pinar Akcakaya1, Maggie L Bobbin2,3,4, Jimmy A Guo2,3

  • 1Discovery Biology, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.

Nature
|September 14, 2018
PubMed
概括

一种新的方法,即体内非目标基因验证 (VIVO),可靠地在体内检测出CRISPR-Cas的非目标基因突变. VIVO 显示基因编辑在小鼠肝脏中是安全有效的.

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