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触觉和触觉神经病痛的敏感性是由皮质脊柱投射决定的
Yuanyuan Liu1,2, Alban Latremoliere1,3, Xinjian Li4,5
1F. M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital, Boston, MA, USA.
Nature
|September 14, 2018
概括
大脑
科学领域:
- 神经科学
- 人体感官系统
- 疼痛感知
背景情况:
- 传统的模型集中在向大脑上升的感觉路径上.
- 人们认为上下对知觉的心理影响是大脑局部的.
- 脊皮管 (CST) 主要是一个运动通道.
研究的目的:
- 调查脊髓感官处理的直接上下皮层控制.
- 探索CST在体感知觉中的作用.
- 了解触觉的神经机制.
主要方法:
- 来自体感皮层的检查皮质脊髓神经元 (CSN).
- 在小鼠中减少了CSN活动或切割了CST.
- 对触觉和有害刺激的行为反应,以及触觉.
主要成果:
- 减少体感神经网络活动或中枢神经系统切割,损害轻触反应.
- 这些操作没有影响对有害刺激的反应.
- CSN操纵减弱了触觉,并揭示了脊柱-皮层-脊柱敏感循环.
结论:
- 脊柱体感官处理的直接皮质调节存在.
- 在正常和病态触觉中发挥作用.
- 这些发现表明神经性疼痛的新治疗点.
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