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Updated: Jul 7, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

一个结合部位决定了Tetrahymena pre-rRNA自剪接,转剪接和RNA酶活性的序列特异性

M D Been, T R Cech

    Cell
    |October 24, 1986
    PubMed
    概括

    这项研究探讨了Tetrahymena前核糖体RNA (rRNA) 干预序列 (IVS),揭示了特定的基配对规则如何控制RNA酶活性. 改变序列会影响拼接精度和其他催化功能,表明RNA酶特异性的可预测变化.

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