支气管切除的进展:内型,遗传学,微生物组和疾病异质性
Patrick A Flume1, James D Chalmers2, Kenneth N Olivier3
1Department of Medicine and Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
Lancet (London, England)
|September 15, 2018
概括
由于其多样性,导致呼吸道扩张的肺部疾病缺少向治疗. 基于患者内型和表型的新分类可能使有效治疗的开发成为可能.
科学领域:
- 肺部医学
- 呼吸系统研究
- 临床试验
背景情况:
- 支气管扩张是由病态的气道扩张,呈异质的定义.
- 目前的治疗方法有限,除了囊性纤维化相关病例之外,还没有批准的治疗方法.
- 疾病异质性使临床实践和临床试验终点的实现复杂化.
研究的目的:
- 探索近期了解支气管异质性的进展.
- 通过内型和表型来讨论患者分类的新方法.
- 突出开发向治疗的潜力.
主要方法:
- 对近期支气管切除研究的观察和进展进行了回顾.
- 分析内型和遗传研究.
- 包括与微生物组相关的发现.
主要成果:
- 最近的洞察力提高了对支气管切除症复杂性的理解.
- 根据内型或表型对患者进行分类是更有效的策略.
- 遗传学和微生物组研究的进步提供了新的视角.
结论:
- 根据内型或表型对支气管切除患者进行分类至关重要.
- 这种方法可能有助于开发特定且有效的疗法.
- 进一步研究遗传学和微生物组是促进治疗的关键.
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