基于的小而明亮的升级纳米粒子
Ting Cheng1, Riccardo Marin1, Artiom Skripka1
1Centre Énergie, Matériaux et Télécommunications , Institut National de la Recherche Scientifique, Université du Québec , Varennes , Quebec J3X 1S2 , Canada.
Journal of the American Chemical Society
|September 15, 2018
概括
研究人员为生物医学应用开发了小型,明亮的升级纳米粒子 (UCNP). 这些纳米粒子有效地将近红外 (NIR) 光转化为紫外线 (UV),使光动力疗法等治疗能够更深入地穿透组织.
科学领域:
- 纳米技术
- 生物医学工程
- 材料科学
背景情况:
- 紫外线 (UV) 辐射对于瘤治疗是有效的,但其组织透率有限.
- 接近红外线 (NIR) 的光深入组织,但缺乏光化学过程的能量.
- 上转化纳米粒子 (UCNP) 将NIR转化为紫外线,但需要更大的尺寸以提高效率,从而阻碍细胞吸收.
研究的目的:
- 为生物医学应用开发小型高效的UCNP.
- 克服UCNP大小和NIR-UV升级效率之间的权衡.
- 创建适合深层组织光介导疗法的UCNP.
主要方法:
- 通过控制连接物比率 (oleylamine/oleic acid) 合成了5nm的UCNP.
- 在油酸中通过回火稳定UCNP以产生10nm以下的晶体.
- 在UCNP核心上生长,以显著提高NIR-to-UV升级效率.
主要成果:
- 实现化学稳定,单分散10nm以下的UCNP.
- 在生长后,NIR-to-UV转换的数量级改进.
- 在升级转换效率方面,LiYbF4:Tm3+/LiYF4 UCNPs的表现优于更大的黄金标准UCNPs.
结论:
- 这两步的策略产生了适合生物医学使用的小型,明亮的UCNP.
- 这些UCNP结合了深层组织透 (NIR) 和高效的紫外线发射.
- 开发的UCNP显示了光介导瘤治疗的巨大潜力.
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