用三种甲等价物对埃诺的催化环氧化
Conner M Farley1, You-Yun Zhou1, Nishit Banka1
1Department of Chemistry , Purdue University , 560 Oval Drive , West Lafayette , Indiana 47907 , United States.
Journal of the American Chemical Society
|September 15, 2018
概括
研究人员开发了一种合成循环有机分子的新催化方法. 这种还原性cocyclooligomerization反应有效地使用一个enone和carbene等价物形成cyclopentanes.
科学领域:
- 有机化学
- 催化剂
- 合成方法
背景情况:
- 循环结构在有机化学中普遍存在,需要有效的合成路径.
- 循环聚合反应为环形成提供了有吸引力的途径,但在控制环大小选择性方面面临挑战.
研究的目的:
- 开发一种用于合成环的新型催化方法.
- 解决循环聚合反应中环大小选择性的挑战.
主要方法:
- 一个和三个碳等价物的催化还原性共聚合.
- 使用 (二氧化) 催化剂和CH2Cl2/Zn作为C1来源.
- 通过金属循环中间体研究反应机制.
主要成果:
- 通过正式的 [2 + 1 + 1 + 1] 循环添加成功合成环丹.
- 基于金属循环路径的演示,涉及连续的迁移插入.
- 产生比环烯更大的环烯.
结论:
- 开发的方法为构建环胺环提供了一种新的策略.
- 反应通过一种独特的金属循环机制进行.
- 这种方法扩大了催化循环聚合反应的范围.
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