将三元螺旋组合成带状纳米和微观结构的可逆层次组合
Monessha Nambiar1, Li-Sheng Wang2, Vincent Rotello2
1Department of Chemistry , Purdue University , 560 Oval Drive , West Lafayette , Indiana 47907-2084 , United States.
Journal of the American Chemical Society
|September 18, 2018
概括
研究人员开发了形成有序纳米结构的自组合. 这些生物材料可以通过pH控制,
科学领域:
- 超分子化学
- 材料科学
- 生物材料工程
背景情况:
- 的自我组装是创建复杂纳米结构的关键策略.
- 控制基于的材料的组装和性能对于先进的应用至关重要.
研究的目的:
- 设计和合成与双胺功能化的卷状,用于层次组装.
- 研究这些基于的纳米和微观结构的结构特征和组装机制.
- 探索这些材料的生物相关应用潜力,特别是pH控制的药物输送.
主要方法:
- 放射性功能化的卷轴的合成.
- 阶层组装成带状矩形结构的特征.
- 进行X射线散射分析以确定更细致的结构方面和包装.
- 对依赖pH的可逆组件的研究.
主要成果:
- 证明了的分层组装成可调节的纳米和微观结构.
- 确立了芳香组的位置和结构尺寸之间的相关性.
- 通过X射线散射确定了三元体和三元体间芳香相互作用的六角包装.
- 在生理条件和可逆的pH调节下确认容易形成.
结论:
- 用双胺功能化的卷状可以自组合成具有可调度尺寸的等级结构.
- 结构性质受到芳香基的战略位置的影响.
- 这些生物材料具有可逆的pH反应性行为, 适合于药物输送等受控制的生物应用.
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