没有皮层的感觉,运动和学习
Y Kate Hong1, Clay O Lacefield1, Chris C Rodgers1
1Department of Neuroscience, Mortimer Zuckerman Mind Brain Behavior Institute and Kavli Institute for Brain Science, Columbia University, New York, NY, USA.
Nature
|September 19, 2018
概括
主体感官皮层对于使用胡须来检测物体并非必不可少. 在被禁用后,小鼠的功能迅速恢复,
科学领域:
- 神经科学
- 感官系统
- 大脑皮层功能
背景情况:
- 大脑皮层在感官检测中的作用受到争议.
- 活动感应涉及协调的感觉和运动系统.
研究的目的:
- 调查主体感官皮层对于主动物体检测的必要性.
- 探索经验在感官皮层失活后的恢复中的作用.
主要方法:
- 使用光遗传学和永久性病变来禁用小鼠的主要体感皮质.
- 训练小鼠使用面部胡须检测物体作为水奖励.
- 在失活后评估行为恢复和任务获取.
主要成果:
- 无能化最初影响了检测,突出了感觉运动联系.
- 小鼠迅速恢复了完全的行为能力, 展示了经验依赖的可塑性.
- 在学习之前的除并没有阻碍任务获取.
结论:
- 主体感官皮质可能不需要用于主动物体检测.
- 其他大脑结构可以弥补感官皮层损伤.
- 经验和可塑性有助于迅速恢复功能.
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