通过序列和交替单单元单体插入制备的离散和立体特异性寡合物
Zixuan Huang1, Benjamin B Noble2, Nathaniel Corrigan1
1Centre for Advanced Macromolecular Design and Australian Centre for NanoMedicine, School of Chemical Engineering , UNSW , Sydney , NSW 2052 , Australia.
Journal of the American Chemical Society
|September 20, 2018
概括
研究人员开发了一种新方法来制造具有精确序列和立体化学的合成聚合物. 这种照片RAFT SUMI技术允许控制,一次插入一个单元的循环单体,实现高的跨选择性.
科学领域:
- 聚合物化学
- 有机合成
- 材料科学
背景情况:
- 自然生物聚合物表现出精确的结构 (分子重量,单体序列,立体规律性) 对于它们的生物功能至关重要.
- 合成聚合物提供化学多样性和更简单的操作,以模仿生物聚合物的精度.
- 复制合成聚合物的结构完美是理解它们化学功能的关键.
研究的目的:
- 开发一种用于合成序列控制和立体特异性寡合物的新方法.
- 调查照片RAFT SUMI对于精确的聚合物构造的潜力.
- 探索周期性单体插入的立体化学结果.
主要方法:
- 使用交替的基链生长和顺序的光诱导RAFT单元单体插入 (光RAFT SUMI).
- 采用了两个周期性单体家族:内和N替代的化物.
- 研究了单体插入RAFT剂的立体选择性.
主要成果:
- 通过循环单体的顺序和交替添加来实现序列控制.
- 在将循环单体插入RAFT剂中显示出高的跨选择性.
- 观察到循环单体产生跨选择性,而非循环单体则产生混合 cis/trans 插入.
结论:
- 照片RAFT SUMI方法可以制备由序列控制和立体特异的合成寡合物.
- 循环单体中的固体阻碍驱动高度跨选择性的聚合物链生长.
- 这种方法为结构精确的合成聚合物提供了途径,类似于天然的生物聚合物.
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