一种释放硫化的红光激活的特征和生物活性 (II) 复合物
Joshua J Woods1,2, Jian Cao3, Alexander R Lippert3
1Robert F. Smith School for Chemical and Biomolecular Engineering , Cornell University , Ithaca , New York 14853 , United States.
Journal of the American Chemical Society
|September 20, 2018
概括
研究人员开发了一种基于的新型剂,只有在被红光激活时才能释放硫化 (H2S). 这种受控释放保护心脏细胞免受伤害,为研究H2S的治疗潜力提供了一个新的工具.
科学领域:
- 生物化学 生物化学
- 化学生物学 化学生物学
- 医学化学 医学化学
背景情况:
- 硫化 (H2S) 是一种关键的气传递物,具有治疗性潜力,用于缺血-再输液损伤.
- 当前的H2S释放前药物经常遭受通过水解不受控制的释放,限制了它们的治疗应用.
- 有效的细胞内H2S输送需要复杂的前药物策略.
研究的目的:
- 开发一种具有时空控制的新型H2S释放剂.
- 为了研究活细胞中通过红光照射激活H2S释放.
- 为了评估光激活的H2S释放对缺血-再输液损伤的保护作用.
主要方法:
- 基于Ru (II) 的H2S释放化合物的合成和特征.
- 在活着的H9c2心肌细胞中显示红光触发的H2S释放.
- 细胞活力的评估和对体外缺血-再输液损伤模型的保护.
主要成果:
- 合成了一种基于Ru (II) 的化合物,在红光激活时可选择性释放H2S.
- 细胞内H2S水平仅在红光照射后显著增加.
- 红光激活的H2S释放为H9c2心肌细胞提供了显著的保护,防止缺血-再输液损伤.
结论:
- 红光激活的H2S释放剂可以精确控制气体传递器的输送.
- 这项技术为研究H2S.的生物学作用和治疗应用提供了有价值的工具.
- 开发的药物显示出针对性治疗的潜力,例如缺血-再输液损伤等疾病.
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