Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Mitotic Spindle02:27

The Mitotic Spindle

8.0K
The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures...
8.0K
Nuclear Binding Energy02:13

Nuclear Binding Energy

14.8K
The difference between the calculated and experimentally measured masses is known as the mass defect of the atom. In the case of helium-4, the mass defect indicates a “loss” in mass of 4.0331 amu – 4.0026 amu = 0.0305 amu. The loss in mass accompanying the formation of an atom from protons, neutrons, and electrons is due to the conversion of that mass into energy that is evolved as the atom forms. The nuclear binding energy is the energy produced when the atoms’ nucleons are bound...
14.8K
Nuclear Stability03:18

Nuclear Stability

23.3K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
23.3K
Nuclear Fusion02:45

Nuclear Fusion

33.9K
The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
33.9K
Systematic Error: Methodological and Sampling Errors01:15

Systematic Error: Methodological and Sampling Errors

11.0K
In the case of systematic errors, the sources can be identified, and the errors can be subsequently minimized by addressing these sources. According to the source, systematic errors can be divided into sampling, instrumental, methodological, and personal errors.
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...
11.0K
Outer Layers of the Cell Envelope01:18

Outer Layers of the Cell Envelope

1.1K
The outermost layers of prokaryotic cells play a critical role in their survival, virulence, and interaction with the environment. These layers, often composed of polysaccharides, polypeptides, or proteins, form protective and adhesive structures that vary in organization and function.Capsules and Slime LayersCapsules are highly organized, tightly bound layers that firmly attach to the bacterial cell wall. Capsules are usually made of polysaccharides, though some are made of polypeptides. These...
1.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A CDK1 phospho-switch reprograms TRAIP to unload replisomes in mitosis.

Science (New York, N.Y.)·2026
Same author

A coordinated transcriptional program controls de novo Golgi biogenesis.

The EMBO journal·2026
Same author

Haplotype-resolved reconstruction and functional interrogation of cancer karyotypes.

Cell systems·2026
Same author

Components of an ESCRT-independent nuclear envelope assembly pathway.

bioRxiv : the preprint server for biology·2026
Same author

BayesCNV: A Bayesian Hierarchical Model for Sensitive and Specific Copy Number Estimation in Cell Free DNA.

Diagnostics (Basel, Switzerland)·2026
Same author

The kinetochore corona orchestrates chromosome congression through transient microtubule interactions.

Proceedings of the National Academy of Sciences of the United States of America·2026

相关实验视频

Updated: Feb 5, 2026

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
07:14

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

8.7K

核膜组装缺陷将线粒错误与染色体结合联系起来

Shiwei Liu1,2,3, Mijung Kwon1,2,3, Mark Mannino1,2,3

  • 1Howard Hughes Medical Institute, Chevy Chase, MD, USA.

Nature
|September 21, 2018
PubMed
概括
此摘要是机器生成的。

核外组合的缺陷导致微核脆弱,导致DNA损伤和癌症. 螺旋微管阻断了微核中的必需蛋白质进口,导致基因组不稳定.

更多相关视频

In Vitro Nuclear Assembly Using Fractionated Xenopus Egg Extracts
04:49

In Vitro Nuclear Assembly Using Fractionated Xenopus Egg Extracts

Published on: September 2, 2008

11.7K
Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
12:04

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

10.7K

相关实验视频

Last Updated: Feb 5, 2026

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
07:14

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

8.7K
In Vitro Nuclear Assembly Using Fractionated Xenopus Egg Extracts
04:49

In Vitro Nuclear Assembly Using Fractionated Xenopus Egg Extracts

Published on: September 2, 2008

11.7K
Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
12:04

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

10.7K

科学领域:

  • 细胞生物学
  • 遗传学
  • 分子生物学

背景情况:

  • 核包膜缺陷与人类疾病有关.
  • 微核的形成可能导致染色体,
  • 微核膜脆弱的原因尚不清楚.

研究的目的:

  • 研究微核外脆弱性的分子基础.
  • 确定导致微核中的DNA损伤和基因组不稳定性的因素.

主要方法:

  • 通过先进的显微镜研究了微核中的核包装.
  • 分析了核心和非核心核包膜蛋白质的进口.
  • 研究了线微管在核膜形成中的作用.

主要成果:

  • 微核具有缺陷的核外组合,进口的非核心蛋白质如核孔综合体 (NPC).
  • 螺旋微管阻碍NPC组装在滞后的染色体上,导致不可逆转的核外缺陷.
  • 将染色体从中分离,可以纠正这些缺陷,并防止DNA受损.

结论:

  • 微核外的脆弱性源于螺旋微管阻断NPC形成的组装缺陷.
  • 在线粒离出过程中染色体分离和核包装之间的松散协调导致基因组不稳定.
  • 缺少精确的检查点控制可以解释频繁的错误和灾难性的基因组重组.