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相关概念视频

Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

6.3K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
6.3K
Pyruvate Oxidation01:15

Pyruvate Oxidation

169.0K
After glycolysis, the charged pyruvate molecules enter the mitochondria via active transport and undergo three enzymatic reactions. These reactions ensure that pyruvate can enter the next metabolic pathway so that energy stored in the pyruvate molecules can be harnessed by the cells.
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
169.0K
Oxidation Numbers03:14

Oxidation Numbers

42.8K
In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
42.8K
Energy-releasing Steps of Glycolysis01:28

Energy-releasing Steps of Glycolysis

146.9K
Glycolysis is divided into two phases based on whether energy is utilized or released. While the first phase consumes ATP, the second phase produces energy in the form of ATP and NADH. The energy is released over a sequence of reactions that turns G3P into pyruvate. The energy-releasing phase—steps 6-10 of glycolysis—occurs twice, once for each of the two 3-carbon sugars produced during steps 1-5 of the first phase.
The first energy-releasing step—the 6th step of glycolysis...
146.9K
Oxidation-Reduction Reactions03:11

Oxidation-Reduction Reactions

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Oxidation–Reduction Reactions
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Oxidation of Alcohols02:37

Oxidation of Alcohols

16.1K
In this lesson, the oxidation of alcohols is discussed in depth. The various reagents used for oxidation of primary and secondary alcohols are detailed, and their mechanism of action is provided.
The process of oxidation in a chemical reaction is observed in any of the three forms:
16.1K

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相关实验视频

Updated: Feb 5, 2026

Analytical Techniques for Assaying Nitric Oxide Bioactivity
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Analytical Techniques for Assaying Nitric Oxide Bioactivity

Published on: June 18, 2012

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释放氧化的环氧化

Haibao Jin1, Lei Yang1, Mona Jasmine R Ahonen1

  • 1Department of Chemistry , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.

Journal of the American Chemical Society
|September 21, 2018
PubMed
概括

新的环氧化 (CD) 衍生物释放氧化 (NO) 来对抗Pseudomonas aeruginosa. 量身定制的NO释放和外观修饰增强了抗菌活性,显示了双药物递送的潜力.

科学领域:

  • 生物材料科学
  • 医学化学
  • 提供药物

背景情况:

  • 循环素 (CD) 是多功能宿主,具有药物输送和治疗潜力.
  • 氧化 (NO) 具有显著的抗菌性质,但需要控制的输送系统.
  • 开发新型释放NO的材料对于对抗抗生素耐药性病原体至关重要.

研究的目的:

  • 合成和描述新的二次氨基基改性循环素 (CD) 衍生物.
  • 用于控制释放的应用,将这些衍生品与氧化 (NO) 供体功能化.
  • 评估这些NO释放的CD衍生物的抗菌功效和潜在的治疗应用.

主要方法:

  • 用各种终端组合成二次氨基修饰的CD衍生物.
  • 在性条件下氧化 (NO) 气体结合形成N-二酸盐供体.
  • 量化NO有效载荷和确定NO释放动力学 (半衰期).
  • 对Pseudomonas aeruginosa的杀菌活性进行评估.
  • 对哺乳动物L929小鼠纤维细胞的细胞毒性评估.
  • 通过promethazine证明了双药物传递能力.

主要成果:

  • 已经成功合成了多种二次氨基基改性CD衍生物.

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  • 达到可调节的NO有效载荷 (0.6-2.4μmol/mg) 和释放半衰期 (0.7-4.2小时).
  • 已证明对Pseudomonas aeruginosa具有强烈的杀菌活性,这取决于NO的有效载荷和外部修饰.
  • 确定了对P. aeruginosa具有高度有效性的初级氨基终端CD.
  • 只有在初级氨基终结的替CD衍生物中观察到细胞毒性.
  • 展示了像普罗美这样的双药物输送的潜力.

    • 结论:

    • 新型释放NO的CD衍生品具有可调节的抗菌特性.
    • 高NO密度和主要氨基功能增强了对P. aeruginosa的杀菌效果.
    • 这些释放NO的CD显示出对抗细菌感染的治疗方法有前途.
    • 两种药物交付应用的潜力扩大了它们的治疗效用.