蛋白质电子:接触器的化学调节 控制金-亚苏林-金交叉点的能量水平对齐
Journal of the American Chemical Society
|September 21, 2018
概括
化学修饰蛋白质电极合控制生物分子结合中的电子传输. 这种方法在没有外部门的情况下调整共振和非共振道之间的传输机制,使电子设备的精确控制成为可能.
科学领域:
- 生物分子电子
- 分子自组
- 收费运输
背景情况:
- 控制生物分子之间的电荷传输对于生物分子电子来说至关重要.
- 固态连接为研究生物分子中的电子运输提供了一个平台.
研究的目的:
- 证明电极-分子合的化学调制用于控制生物分子结合中的ETp.
- 通过化学修饰来研究共振和非共振道机制之间的切换.
主要方法:
- 在石版制备的金电极连接中利用蛋白质亚苏林 (Az).
- 通过 Au-S 键和链接分子与 Az 共同功能化的黄金电极.
- 通过氨基酸键的形成改变了链接蛋白的合,以改变ETp机制.
主要成果:
- 通过化学调节电极与青之间的合来控制ETp.
- 通过改变胺结合,证明ETp机制从共振到非共振道.
- 确定不同电极-蛋白质合配置的青色边界轨道能量.
结论:
- 电极-分子合的化学修饰提供了一种控制生物分子结合中的ETp的方法.
- 这种方法可以在没有门电极的双终端设备中实现可调节的电子特性.
- 开辟了生物分子电子设备的定性和定量控制的途径.
相关概念视频
Contact-dependent Signaling
47.5K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
Gap Junctions
In animal cells, gap junctions are formed...
47.5K
Electron Behavior
109.0K
Overview
Electrons are negatively charged subatomic particles that are attracted to an orbit around the positively-charged nucleus of an atom. They reside in locations that are associated with energy levels called shells and are further organized into sub-shells and orbitals within each shell.
Electrons Orbit the Nucleus
Electrons are found in specific locations outside of the nucleus. The shell in which an electron resides indicates the general energy level of the electron: those closer to the...
Electrons are negatively charged subatomic particles that are attracted to an orbit around the positively-charged nucleus of an atom. They reside in locations that are associated with energy levels called shells and are further organized into sub-shells and orbitals within each shell.
Electrons Orbit the Nucleus
Electrons are found in specific locations outside of the nucleus. The shell in which an electron resides indicates the general energy level of the electron: those closer to the...
109.0K
Physical and Chemical Properties of Matter
166.5K
The characteristics that enable us to distinguish one substance from another are called properties.
166.5K
Ionization Energy
43.4K
The amount of energy required to remove the most loosely bound electron from a gaseous atom in its ground state is called its first ionization energy (IE1). The first ionization energy for an element, X, is the energy required to form a cation with 1+ charge:
43.4K
Energy Transfer in Chemical Reactions
11.8K
Chemical reactions require sufficient energy to cause the matter to collide with enough precision and force that old chemical bonds can be broken and new ones formed. In general, kinetic energy is the form of energy powering any type of matter in motion. Imagine a person building a brick wall. The energy it takes to lift and place one brick on top of another is the kinetic energy—the energy matter possesses because of its motion. Once the wall is in place, it stores potential energy.
11.8K
Chemical Agents for Microbial Control
896
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
896


