通过纵向个人监测揭示的动态人类环境暴露体
Chao Jiang1, Xin Wang1, Xiyan Li1
1Department of Genetics, Stanford University School of Medicine, Stanford, CA 94304, USA.
Cell
|September 23, 2018
概括
人类暴露于生物和化学环境因素是巨大的和动态的. 这项研究揭示了个人暴露组是复杂的,取决于位置的网络, 影响人类健康.
科学领域:
- 环境健康科学
- 毒理学
- 微生物学
背景情况:
- 人类健康与环境暴露密切相关.
- 这些暴露的全部范围和变化在很大程度上未被描述.
- 了解个人暴露对公众健康至关重要.
研究的目的:
- 开发和应用一种敏感的方法来监测个人在空气中的生物和化学暴露.
- 描述个体曝光体的动态和时空性质.
- 研究生物和化学暴露及其环境背景之间的关系.
主要方法:
- 对个人空气暴露的敏感监测技术的开发.
- 在66个地理位置追踪15个个体,
- 在个人暴露体中分析生物 (物种) 和化学化合物.
- 构建一个曝光体相互作用网络.
主要成果:
- 人们接触到成千上万种不同的生物物种和化学化合物,
- 个人暴露物表现出显著的动态和时空变化,即使在附近的地理区域内.
- 综合分析显示生物和化学暴露之间存在强烈的位置相关性.
- 一个暴露性互动网络揭示了以人类和环境为中心的相互联系的生态系统.
结论:
- 人类的暴露体非常多样化,充满活力,受时空因素的影响.
- 暴露体代表复杂的相互作用网络,对人类健康有重大影响.
- 这些发现强调需要进行全面的暴露评估以了解健康结果.
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