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一个由肠道诱导的神经回路
Wenfei Han1, Luis A Tellez2, Matthew H Perkins3
1The John B. Pierce Laboratory, New Haven, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cell
|September 25, 2018
概括
肠-大脑轴对动机和情绪有很大影响. 激活特定的肠内神经元会触发奖励通路,
科学领域:
- 神经科学
- 胃肠病学
- 精神病学
背景情况:
- 人们越来越认识到肠道在调节情绪和动机状态方面的作用.
- 然而,连接肠道与大脑奖励系统的特定神经回路基本上没有被描述.
研究的目的:
- 为了阐明奖励背后的肠-大脑神经回路.
- 调查神经元在奖励途径中介的作用.
主要方法:
- 通过光学激活肠道内神经元.
- 自我刺激的行为测试, 味道, 和地点调节.
- 细胞特异性的超神经追踪.
- 在黑色物质中测量多巴胺释放.
主要成果:
- 激活了右侧的感觉,但没有左侧,持续的自我刺激行为和诱导的奖励.
- 这种激活导致黑色素和条件偏好的多巴胺释放.
- 超神经追踪发现了一条特定的途径,从右性感官,通过背侧侧区域,到黑色素体多巴胺细胞.
- 激活这一对内投射模仿了右刺激的奖励效果.
结论:
- 肠道至大脑轴是大脑神经奖励通路的关键组成部分.
- 这些发现表明,向道可能为情绪障碍提供新的治疗策略.
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