与抗HIV-1抗体的联合治疗维持病毒抑制
Pilar Mendoza1, Henning Gruell2,3,4, Lilian Nogueira1
1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Nature
|September 28, 2018
概括
在临床试验中测试了两种广泛中和抗体,3BNC117和10-1074,用于HIV-1治疗中断. 在没有抗逆转录病毒治疗的参与者中,这种抗体组合成功抑制了HIV-1.
科学领域:
- 免疫学
- 病毒学
- 临床医学
背景情况:
- 抗逆转录病毒治疗 (ART) 对于治疗HIV-1感染至关重要,因为治疗中断后病毒会迅速反弹.
- 广泛中和抗体 (bNAbs) 为艾滋病毒-1 控制提供了潜在的替代或辅助方法.
- 在治疗中断期间了解bNAb组合的疗效对于开发新的HIV-1治疗策略至关重要.
研究的目的:
- 在HIV-1患者的分析性治疗中断 (ATI) 中评估两种bNAbs,3BNC117和10-1074的联合治疗的安全性和有效性.
- 在接受bNAb输液而不是ART的参与者中评估病毒抑制的持续时间和病毒耐药性的出现.
主要方法:
- 进行了一项1b期临床试验,涉及9名HIV-1患者.
- 在ATI期间,参与者分别在0,3周和6周接受了3BNC117和10-1074抗体组合的输液.
- 在整个研究期间对病毒载量,抗体耐药性和安全性进行了监测.
主要成果:
- 3BNC117和10-1074的组合通常被很好地容忍.
- 所有具有抗体敏感潜伏病毒储存的9名参与者均保持了病毒抑制的中位数为21周 (范围:15->30周).
- 没有参与者对3BNC117和10-1074产生抗药性.
结论:
- 在没有ART的情况下,抗HIV-1单克隆抗体3BNC117和10-1074的组合可以有效地维持长期的病毒抑制.
- 这种bNAb组合是HIV-1管理的有希望的策略,特别是在易受病毒感染的个体中.
- 需要进一步的研究来探索这种基于抗体的方法的长期耐用性和潜力.
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