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Updated: Feb 4, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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一个GPCR中的自然变异和工程突变促进了C. elegans的DEET耐药性

Emily J Dennis1, May Dobosiewicz2, Xin Jin2,3

  • 1Laboratory of Neurogenetics and Behaviour, The Rockefeller University, New York, NY, USA.

Nature
|September 28, 2018
PubMed
概括

通过破坏嗅觉通路,N,N-甲胺 (DEET) 扰乱了昆虫和线虫的行为. 研究人员在C. elegans中发现了一个特定的基因,str-217,以及对DEET必不可少的ADL神经元

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